Beilstein J. Org. Chem.2017,13, 1008–1021, doi:10.3762/bjoc.13.100
: gold nanoparticles; glyconanoparticles; glyconanomaterials; immunology; targeting; Introduction
Carbohydrates are well recognized as crucial biomolecules for their capability to produce an enormous number of biocodes which are translated into their ability to promote or suppress a plethora of
resulting biological processes [3][4].
The increasing ability to manipulate material at the nanosize allowed the development of many glyconanoparticles helpful in a wide range of applications, from the drug delivery to the imaging [5][6][7]. Among the large number of nanomaterials, gold is one of the main
exploited scaffolds for producing glyconanoparticles [3][4]. First of all, gold is an extremely inert and biocompatible material. At nanosize, gold nanoparticles (AuNPs) are characterized by unique optical features which result extremely useful in many diagnosis and affinity studies or protocols. Moreover
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Graphical Abstract
Figure 1:
Schematic overview on the glyco-gold nanoparticles synthetic approaches.
Beilstein J. Org. Chem.2010,6, No. 58, doi:10.3762/bjoc.6.58
polymer surfactants for the colloidal stabilization of polycaprolactone (PCL) nanoparticles. Preliminary studies towards the recognition of these glyco-nanoparticles by specific concanavalin A (con A) lectin have been carried out, which provided clear evidence for the presence of carbohydrate units on the
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Graphical Abstract
Figure 1:
Preparation of the 8-azido-3,6-dioxaoctyl α-D-mannopyranoside.